Ohio State’s P4 Medicine Update Jan. 24, 2012

Captured by Sherri Kirk

Clay Marsh (The Center for Personalized Health Care) a Semi-Finalist for Innovation Award

On Thursday, February 2, 2012 the annual TechColumbus Innovation Awards will showcase central Ohio’s many achievements by honoring its top innovators. It is a night of networking, prestige, and celebration. Winners in 13 award categories will be announced to an audience of 1,100+ attendees.

Under the executive leadership of Dr. Clay Marsh, Ohio State’s Center for Personalized Health Care is expand »a semi-finalist in the Innovation in Non-Profit Service Delivery category. CPHC was selected for its novel approach to transforming healthcare delivery from its current reactive mode of sick care, to a more proactive one that makes health care more predictive, preventive, personalized and participatory – P4 Medicine. The future of medicine focuses on creating systems and processes to deliver key evidence-based practices and to stratify individuals into smaller precise populations to deliver these key interventions.

The goal of P4 Medicine is to reduce healthcare costs, improve outcomes and deliver higher quality health care to patients. It embraces the interface between an individual’s unique DNA, environment and behavior to choose the right intervention at the right time for the right person. P4 Medicine utilizes advances in genomics and molecular diagnostics discoveries to provide predictive information that is necessary to tailor, or personalize, disease management approaches for each individual. Ohio State’s Medical Center is pioneering the advancement of P4 Medicine to improve people’s lives.

The TechColumbus Innovation Awards celebrate the spirit of innovation by recognizing outstanding technology achievements in central Ohio. This prestigious evening showcases the region’s advancements and promising future. For more information, visit: www.techcolumbusinnovationawards.org

OSU Medical Center leaders chat about P4 Medicine on ONN

 

 

 

 

 

 

 

Steven Gabbe and Clay Marsh were interviewed by the host of the Ohio Means Business program on Ohio News Network and discussed the elements of P4 medicine, how it will transform health care, barriers and challenges of implementation and recent successes in P4 medicine spearheaded by the Center for Personalized Health Care.

OSU’s Center for Personalized Health Care (CPHC) is earning international distinction through its leadership in a novel approach to personalized healthcare known as P4 Medicine – predictive, preventive, personalized and participatory medicine. P4 Medicine focuses on creating systems to deliver health care focused on bringing the right intervention or treatment to the right person at the right time to save money and improve outcomes. P4 Medicine will enable the delivery of key evidence-based practices to reduce healthcare costs and improve outcomes, and leverage the interface between an individual’s unique DNA, environment and behavior to promote health and wellness. P4 Medicine utilizes advances in genomics and molecular diagnostics to provide predictive information that is necessary to tailor, or personalize, disease-management approaches for each individual. Therapeutics and health management tools are being developed to help prevent disease instead of merely treating the symptoms. Medicine of the future will also be participatory. Patients will have access to a single portal that electronically stores their medical records and genetic profiles in addition to tools that analyze these data and provide precise strategies to promote wellness. In addition, social networking and the power of games are instrumental to engaging the consumer to taking ownership of their own health care.

Under the executive leadership of Dr. Clay Marsh, the CPHC advocates for the creation and implementation of a scalable system of healthcare. The result is a tailored approach to wellness, disease prevention and, when required, health care. The CPHC facilitates research, education, prevention and treatments designed to meet patients’ individual needs. Its missions are to create a pipeline for innovation and accelerate the application and dissemination of discovery to realize the promise of personalized health care/P4 Medicine, and to advocate for this approach locally, nationally and internationally.

Watch video here – http://www.youtube.com/watch?v=arFBw5iXKmw

The Rise of Genetics-Based Medicine

Source: MDNews.com

This issue of MD News deals with “The Future of Health Care,” so this month, I wanted to provide my perspective on the future of health care in the area of pharmaceutical therapies.

As a compounding pharmacist, my view may be skewed, but I see medication therapies becoming focused more and more on the individual and less on generic patient populations.

Medical treatments are already personalized, as patients are assessed before a treatment is selected for them. However, it is widely known that any drug can be therapeutic for some individuals while ineffective for others, triggering adverse effects in some patients while others tolerate the same therapy without adverse side effects.

As we learn more about the genetic makeup of an individual and which genes trigger what responses, a new approach to medicine is quickly approaching that will utilize breakthroughs in technologies dealing with genetic information and patients’ responses to drug treatments.

Personalized health care will use molecular analysis and individuals’ genetic profiles to tailor drug treatments that achieve optimal medical outcomes. The association of individuals with a particular gene variant will be used in the future to prescribe the most efficient drug treatment while avoiding adverse reactions. In addition, this medical revolution based on genetic information is expected to predict disease risk, therefore allowing individuals to address these risks while they are still healthy. This will cause a shift toward a prevention-focused health care system and stimulate proactive behavior among the public.

Click here to read more.

Mayo Clinic plans to sequence patients’ genomes to personalise care

Source: TheGuardian

Project will give doctors the genetic information they need to choose drugs that work best and minimise side effects.

Doctors have drawn up plans to sequence the full genetic code of thousands of people in a landmark project to personalise their medical care.

Volunteers will have all six billion letters of their genome read, stored and linked to their medical records to help doctors prescribe more effective drugs and other therapies.

The prestigious Mayo Clinic in the US will launch the pilot study early next year as part of an ambitious move towards an era of “proactive genomics” that puts modern genetics at the centre of patient care.

The trial reflects a growing trend in medicine to use genetic information to identify those patients who will benefit most from a drug and those who will respond better to an alternative.

Other medical centres around the world that are thinking of introducing their own whole genome tests will be watching the trial with interest.

The wealth of information locked up in the human genome can help doctors advise patients on lifestyle changes to stave off diseases they are at risk of developing, but in many cases that advice is familiar and generic – for example focusing on healthy eating, regular exercise, drinking in moderation and not smoking.

Click here to read more.

The Rising Clout of the Patient

Source: PharmaExec.com

In 2011, the patient’s clout as a stakeholder was firmly established, as reflected in several industry conferences. What’s next for the patient in 2012?

In 2011, many healthcare organizations came around to the idea that patients should be included in discussions that had customarily taken place about them, but without their direct participation. This shift was evident at several healthcare conferences last year, and bodes well for 2012 as a year when further overtures – and partnerships – will be formed with and between patients.

Health2.0

The Health2.0 conference in San Francisco brought a deluge of innovation and shiny, new healthcare applications. Data plus IT and innovation represent the future of healthcare, and individual patients are a critical component of this equation (not just their data). This was a key theme of the Health2.0 conference. “Patient stories” have often been highlighted at conferences, and used as bookends to infuse a dose of reality to educational sessions.  What impressed me about the Health2.0 conference was the inclusion of patients and caregivers in the conversations, allowing for bi-directional exchange. Patients2.0, an offshoot of Health2.0, is a movement that aims to revolutionize healthcare delivery around the patients. The goal is to leverage the Health2.0 phenomenon and develop a hub for patients to exchange experiences through peer-to-peer networks, to obtain information, and most importantly, to have a collective voice in healthcare decision-making. By sharing stories, co-creating health data, and aggregating issues across the healthcare spectrum, the voices of Patients2.0 are empowered to be part of the larger conversation, and to exert influence on the health system by shaping future policy. Patients are the new healthcare disruption that can help transform the landscape, and using forums such as Health2.0 to involve them every step of the way is truly ahead of the curve.

Click here to read more.

As Smartphones Get Smarter, You May Get Healthier: How mHealth Can Bring Cheaper Health Care To All

Source: Fast Company

Smartphones and tablets are transforming the future of health care. Can we really trust them to save lives?

The average auto refractor–that clunky-looking device eye doctors use to pinpoint your prescription–weighs about 40 pounds, costs $10,000, and is virtually impossible to find in a rural village in the developing world. As a result, some half a billion people are living with vision problems, which make it tough to read and work.

Ramesh Raskar knew fixing this problem would be tricky. It required a new way of thinking about eye tests–and a new kind of device, one powerful enough to support high-resolution visuals, cheap enough to scale, and simple enough to be used by just about anyone. The MIT professor briefly toyed with stand-alone options, which were complicated and costly. Then he reached into his pocket and pulled out an unexpected savior: his iPhone.

“The displays had gotten so good, thanks to people wanting to watch episodes of Lost in high definition,” Raskar recalls. “I was immediately energized.”

By creating an app and attachment for the popular smartphone, Raskar could tap into a huge existing user base and skirt millions in distribution and manufacturing costs. The result: a plastic clip-on eyepiece that uses an on-screen visual test to determine a patient’s “refractive error” (a number doctors then use to dole out prescriptions). When his startup, EyeNetra, begins market testing later this year in Brazil, India, and Mexico–and eventually in the U.S.–its tech will deliver all the functionality of an optometrist’s costly machine for less than $30.

Click here to read more.

Tackling Obesity

Captured by The Ohio State University

One-third of U.S. adults, and an additional 17 percent of children and adolescents, are considered obese according to government body mass index guidelines.

But understanding the origins of obesity is a complex process. Studies increasingly indicate that there are many more influences on body weight than how much we eat or exercise.

A range of research initiatives led by Ohio State scientists shows that varied biological processes and specific areas of the brain also appear to influence the risk for obesity. Some studies suggest that the risk can be traced all the way back to the toddler years.

To read the full story, click here.

New Test Predicts Risk for Recurrence for Patients With DCIS

Source: Newswise

Multigene assay predicts risk for local recurrence for patients with DCIS. This advance combines knowledge of the genome and new molecular technologies. Test allows physicians to individualize treatment so that lower-risk patients avoid radiation.

Click here to read more.

Researchers Test a Drug-Exercise Program Designed to Prevent Type 2 Diabetes

Source: Newswise

Study suggests that exercise and one of the most commonly prescribed drugs for diabetes, metformin, each improves insulin resistance when used alone, but together, metformin blunted the full effect of a 12-week exercise program in pre-diabetic men and women.

Click here to read more.