Tag Archives: center for personalized health care

Washington’s PeaceHealth Joins ISB-led Personalized Medicine Initiative

Captured by GenomeWeb

PeaceHealth, a Washington state-based non-profit health system, has partnered with the P4 Medicine institute, or P4Mi, a non-profit consortium focused on applying personalized medicine in the clinic, the partners announced today.

PeaceHealth said that its partnership with P4 Medicine, which was launched in 2010 by the Institute for Systems Biology and The Ohio State University, will ultimately provide its network of medical centers in Washington, Alaska, and Oregon with new genome-based predictive and diagnostic tools.

The non-profit said that it will work with P4Mi leaders to identify pilot projects that will be launched over the next two years in its medical practices and communities.

P4Mi is centered around the vision of advancing what Leroy Hood, ISB co-founder and president and chairman of P4Mi’s board of directors, calls P4 medicine — healthcare that is predictive, preventive, personalized, and participatory.

“PeaceHealth will help us integrate emerging biologic science into community-based care models, and make innovations in wellness and health accessible to whole communities,” Hood said in a statement.

“Over time, we hope to take rapidly emerging P4Mi health and wellness innovations and integrate them into everyday interactions between PeaceHealth providers and their patients to better predict, prevent, and treat disease,” added Peter Adler, PeaceHealth’s senior VP for strategy, innovation, and development.

The partnership agreement makes PeaceHealth a founding community health partner of P4Mi, along with OSU’s Center for Personalized Health at the Wexner Medical Center.

A Conversation with Clay Marsh, Ohio State University

Captured by MD4Utah

Physician-scientist Clay Marsh is one of the indisputable rising stars in the constellation of personalized health care (a term he doesn’t fancy), and a genuine innovator in devising preventative health care as opposed to “sick care,” and in pursuing novel translational research and pilot projects that find new ways to engage patients in the nation’s largest academic health care system.

Among his multifaceted appointments, Marsh currently serves as Executive Director, Center for Personalized Health Care; Vice Dean and Senior Associate Vice President for Research, College of Medicine; Professor of Internal Medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine; and Director, Center for Critical Care and Respiratory Medicine. He is also a member of the National Summit on Personalized Health Care Board of Directors.

Clay Mash, Ohia State University

MD4 Utah:           How would you describe your program’s business model, in particular related to its approach to scientific inquiry?

Clay Marsh:          Our scientific approach and business model are tightly connected. We are trying to save money and improve outcomes, based on foundational principles. One of our primary goals is value innovation:  less cost, higher quality.

MD4 Utah:           How does this approach translate to strategic objectives?

Marsh:                    Essentially, there are three aspects in the immediate-, mid- and long-range. The most immediate goal is to save money through what we call medical hotspotting: coming up with ways to identify people spending the most on health care, and find solutions for them. The top 1 percent of the CMS patients spent 23 to 30 percent of all of the funds in Medicare/Medicaid, the top 5 percent spend 50 percent and the top 15 percent spend 97 percent of the money, so the bottom half, 50 percent spend about 3 percent of the money. If you want a solution that will save money and improve outcomes in a meaningful way, focus on the people spending all the money because focusing on everybody you will really dilute your ability to bring meaningful solutions to the topline.

We are really interested in trying to predict the topline 5 percent of people using the system, utilizing our own health plan as the paradigm there, and then wanting to understand what are the things we can intervene with to improve their outcomes – whether that’s visiting their homes in person, by computer or telephone, looking at their benefits to see if there are medicines that could cause problems or if the medicines could be substituted with other as-effective but less-costly medicines. What are the top diagnoses of these areas: heart failure or something else, for example? We want to really create critical pathways for these diseases, looking at long-term importance and keeping people at home. We think hot spotting would be one of the easiest ways to reduce costs and improve outcomes.

The critical intermediate focus we have is that healthcare delivery is quite variable, so being able to deliver evidence-based practices is not really effective across our whole health system. We need capabilities and to engineer our delivery systems to automatically deliver the right treatments for the right person at the right time. And this has more to do with workflows and systems engineering of medicine practice, as Clayton Christensen said. We really want to create automatic checklist level systems that bring healthcare down from individual physicians to systems that include nurse practitioners and physicians’ assistants and genetic counselors – but many of these would eventually would be pushed down to electronic medical records. The electronic medical record system may be a personal alarm system for each person.

In the long term, we’re working on something not yet ready for prime time: going from disease-oriented care to health- and wellness-oriented care. First we need to understand what health and wellness is. At the end of the day we want to facilitate driving health and health care, not just sick care. We need people to stay well. This will represent an entire paradigm shift in how we look at health and patient care, and knowledge and measurement need to change dramatically.  These three primary goals are connected on multiple levels.

Click here to read more.

Clay Marsh (The Center for Personalized Health Care) a Semi-Finalist for Innovation Award

On Thursday, February 2, 2012 the annual TechColumbus Innovation Awards will showcase central Ohio’s many achievements by honoring its top innovators. It is a night of networking, prestige, and celebration. Winners in 13 award categories will be announced to an audience of 1,100+ attendees.

Under the executive leadership of Dr. Clay Marsh, Ohio State’s Center for Personalized Health Care is expand »a semi-finalist in the Innovation in Non-Profit Service Delivery category. CPHC was selected for its novel approach to transforming healthcare delivery from its current reactive mode of sick care, to a more proactive one that makes health care more predictive, preventive, personalized and participatory – P4 Medicine. The future of medicine focuses on creating systems and processes to deliver key evidence-based practices and to stratify individuals into smaller precise populations to deliver these key interventions.

The goal of P4 Medicine is to reduce healthcare costs, improve outcomes and deliver higher quality health care to patients. It embraces the interface between an individual’s unique DNA, environment and behavior to choose the right intervention at the right time for the right person. P4 Medicine utilizes advances in genomics and molecular diagnostics discoveries to provide predictive information that is necessary to tailor, or personalize, disease management approaches for each individual. Ohio State’s Medical Center is pioneering the advancement of P4 Medicine to improve people’s lives.

The TechColumbus Innovation Awards celebrate the spirit of innovation by recognizing outstanding technology achievements in central Ohio. This prestigious evening showcases the region’s advancements and promising future. For more information, visit: www.techcolumbusinnovationawards.org

OSU Medical Center leaders chat about P4 Medicine on ONN








Steven Gabbe and Clay Marsh were interviewed by the host of the Ohio Means Business program on Ohio News Network and discussed the elements of P4 medicine, how it will transform health care, barriers and challenges of implementation and recent successes in P4 medicine spearheaded by the Center for Personalized Health Care.

OSU’s Center for Personalized Health Care (CPHC) is earning international distinction through its leadership in a novel approach to personalized healthcare known as P4 Medicine – predictive, preventive, personalized and participatory medicine. P4 Medicine focuses on creating systems to deliver health care focused on bringing the right intervention or treatment to the right person at the right time to save money and improve outcomes. P4 Medicine will enable the delivery of key evidence-based practices to reduce healthcare costs and improve outcomes, and leverage the interface between an individual’s unique DNA, environment and behavior to promote health and wellness. P4 Medicine utilizes advances in genomics and molecular diagnostics to provide predictive information that is necessary to tailor, or personalize, disease-management approaches for each individual. Therapeutics and health management tools are being developed to help prevent disease instead of merely treating the symptoms. Medicine of the future will also be participatory. Patients will have access to a single portal that electronically stores their medical records and genetic profiles in addition to tools that analyze these data and provide precise strategies to promote wellness. In addition, social networking and the power of games are instrumental to engaging the consumer to taking ownership of their own health care.

Under the executive leadership of Dr. Clay Marsh, the CPHC advocates for the creation and implementation of a scalable system of healthcare. The result is a tailored approach to wellness, disease prevention and, when required, health care. The CPHC facilitates research, education, prevention and treatments designed to meet patients’ individual needs. Its missions are to create a pipeline for innovation and accelerate the application and dissemination of discovery to realize the promise of personalized health care/P4 Medicine, and to advocate for this approach locally, nationally and internationally.

Watch video here – http://www.youtube.com/watch?v=arFBw5iXKmw

Coverage Policy for Genetic Tests Should Reflect Clinical Utility

Captured by Managed Healthcare Executive magazine
December issue

Medical science has progressed exponentially in recent years, but the challenge for insurers continues to be determining coverage policies. Clay Marsh, MD, executive director of the Center for Personalized Health Care at The Ohio State University, says some forms of genetic tests are more commonly accepted than others such as the test that looks for BRCA1 or BRCA2 genes in women who have breast cancer. Marsh says some of the earliest research in genetic testing has been done in the area of pharmacogenomics to identify how patients with certain genetic profiles will respond to a drug.
Click here to read the full article.

Ohio State Launches Studies to Motivate, Prevent Cancer in High-Risk Groups

Captured by WBNS-TV/10

Ohio State Launches Studies to Motivate, Prevent Cancer in High-Risk Groups

Carmen Swain of the Center for Personalized Health Care, and program director of the Physical Activity and Educational Services Health and Exercise Science Labs in Life at COSI, participated in a story about cancer prevention. The “Female Focus” segment on WBNS featured ONE GOAL, a study seeking to prevent cancer in women who have a family history of breast, colon or endometrial cancer by improving their physical wellness. Participants are eligible to receive a free body composition assessment, a comprehensive physical fitness test, and a personalized consultation, which includes a review of test results and stresses the importance of physical activity in the reduction of cancer risk. This coverage resulted from pitching efforts and a news release, available on the Web at: http://medicalcenter.osu.edu/mediaroom/releases/Pages/Ohio-State-Launches-Studies-to-Motivate,-Prevent-Cancer-in-High-Risk-Groups.aspx.

WBNS-TV/10 story: http://go.osu.edu/HHE

Meet Ohio State’s Personalized Health Care National Conference Speakers

The Ohio State University’s Center for Personalized Health Care is gathering academic leaders, industry experts, government policymakers and healthcare providers from across the country to discuss the latest developments in P4 Medicine, which is a novel approach to individualized medical care that engages consumer participationpredicts and prevents disease, facilitates health, and creates a personalized life strategy wellness plan for each individual.

The Johanna and Ralph DeStefano Personalized Health Care National Conference will be held Oct. 6-7 at the Blackwell Inn, located at 2110 Tuttle Park Place, on the campus of The Ohio State University.

With a theme of “The Future of P4 Medicine and Its Impact on Clinical Care,” attendees will hear from experts about revolutionizing medicine and transforming healthcare delivery in a way which will result in more precise, cost-effective and higher quality health care for patients. Topics will focus on the infrastructure necessary to enable P4 Medicine, applications of genetics and genomics in clinical medicine, the latest breakthroughs in science, patient engagement and the barriers to making P4 Medicine a reality.

Dr. Clay Marsh, executive director of OSU’s Center for Personalized Health Care,  shares: We are leading the way in bringing P4 Medicine to our patients and consumers, and this year’s conference is focusing on its future and its impact on clinical care. Having visionaries and leaders like Johanna DeStefano support our national conference is a critical factor to bringing P4 Medicine to the community, to reduce costs and improve outcomes of healthcare delivery.

This year’s keynote speakers include:

Leading as the conference’s first keynote speaker and discussing targeted cancer therapies, Dr. William Dalton is a cancer researcher who is interested in basic and translational research in molecular mechanisms of drug resistance and new drug discovery.


Dr. Carlo Croce, a physician-scientist world-renowned for his contributions involving the genes and genetic mechanisms implicated in the pathogenesis of human cancer.


Dr. Ralph Snyderman who developed Prospective Care, a novel approach to strategic health planning rather than reactive treatment of chronic disease, will discuss preventive medicine and healthcare reform.


The final keynote address of the conference will be given by Ann Pendleton-Jullian, who will discuss complex and adaptive systems in health care and making the connections to patient engagement.


Other speakers and expert panelists will discuss:

  • Novel approaches in the prediction and treatment of cancer
  • Advances in the prevention and treatment of cardiovascular disease
  • Community wellness
  • Creating a consumer-focused environment for participatory health care
  • Ohio as a center for healthcare reform, from a CEO’s perspective
  • P4 Medicine as a framework for value innovation (reducing cost and improving outcomes)

For more information about the conference program, registration, participating speakers and P4 Medicine, go to: http://cphc.osu.edu.